Hypothesizing Synergy between Acupuncture/ Auriculotherapy and Natural Activation of Mesolimbic Dopaminergic Pathways: Putative Natural Treatment Modalities for the Reduction of Drug Hunger and Relapse

Kenneth Blum, John Giordano, Siobhan Morse, Arthur Anderson, Javier Carbajal, Roger Waite, Bernarld Downs, Jaclyn Downs, Margaret Madigan, Debmalya Barh, Eric Braverman

Abstract


Acupuncture is a very ancient form of healing which predates recorded history. The philosophy is rooted in the Taoist tradition which goes back over 8000 years. To date this practice although used world-wide to treat addictive behaviors has not been generally accepted or scientifically proven. There are however many positive reports in the literature in its effectiveness in reducing symptoms of withdrawal from alcohol, heroin and cocaine. In addition, due to known neuro-chemical mechanisms associated with acupuncture, especially its role in pain relief and endogenous opioid function, clinical benefits in reward dependence behaviors seem parsimonious. In this review article we are hypothesizing synergy between acupuncture/auriculotherapy and natural activation of mesolimbic dopaminergic pathways to reduce drug hunger and prevent relapse. Following a review of the literature involving both of these modalities the scientific and clinical community is encouraged to carry out translational research in large randomized double-blinded placebo controlled investigations coupling these two anti-craving treatment modalities.


Keywords


Acupuncture; Auriculotherapy; Dopamine; Reward Deficiency Syndrome; Neuroadaptagen Amino –Acid Therapy (NAAT); KB220

Full Text:

PDF

References


Berridge KC (2009) 'Liking' and 'wanting' food rewards: brain substrates and roles in eating disorders. Physiology Behavior, 97: 537-550.

Blum K, Allison D, Trachtenberg MC, Williams RW, Loeblich, LA (1988) Reduction of both drug hunger and withdrawal against advice rate of cocaine abusers in a 30 day inpatient treatment program by the neuronutrient Tropamine. Current Therapeutic Research, 43: 1204-1214.

Blum. K & Braverman, E.R. (2000) Reward deficiency Syndrome: A Biogenetic Model for the Diagnosis and Treatment of Impulsive, Addictive & Compulsive Behaviors., Journal Psychoactive Drugs, 32 (Suppl) 1-112.

Blum K, Chen T, Chen A, Bowirrat, A.; Downs BW, Waite RL, Reinking J, Kerner M, Braverman D, DiNubile N, Rhoades P, Braverman ER, Blum SH, Oscar-Berman M, Paolomo T, Stice E, Gold M, Comings DE, Savarimuthu S (2009) Genes and Happiness. Gene Therapy and Molecular Biology, 13: 82-120.

Blum K, Cull J, Braverman E, Comings D (1996) Reward Deficiency Syndrome. American Scientist. 84:132-45.

Blum K, Chen T, Waite RL, Williams L, Prihoda TJ, Kerner MM, Palomo T, Comings, DE, Tung H, Rhoades P, Oscar-Berman M (2008) Activation instead of blocking mesolimbic dopaminergic reward circuitry is a preferred modality in the long term treatment of reward deficiency syndrome (RDS): a commentary. Theoretical Biology and Medical Modeling, 5: 24

Blum K, Gold MS (2011) Neuro-chemical activation of brain reward meso-limbic circuitry is associated with relapse prevention and drug hunger: a hypothesis. Medical Hypotheses, 76: 576-584

Blum K, Giordano J, Morse S, Liu Y, Tan J, Bowirrat A, Smolen A, Waite R, Downs W, Madigan M, Kerne M, Fornari F, Stice E, Braverman E, Miller D, Bailey J, (2010) Genetic Addiction Risk Score (GARS) Analysis: Exploratory Development of Polymorphic Risk Alleles in Poly-drug Addicted Males. The IIOAB Journal, 1: 1-14.

Blum K, Holder J (2001) 1st Conference on Reward Deficiency Syndrome: Genetic Antecedents and Clinical Pathways. San Francisco, California, USA. November 12-13, 2000, Molecular Psychiatry 6: (1 Suppl 1):S1-8.

Blum K, Newmeyer J, Inaba D, Whitehead C, Smith DE (1978) Acupuncture as a common treatment modality in drug and alcohol dependence: Possible neurochemical rationale. Journal of Psychedelic Drugs, 10: 105 115.

Blum K, Noble EP, Sheridan PJ, Montgomery A, Ritchie T, Jagadeeswaran P, Nogami H, Briggs AH, Cohn JB(1990) Allelic association of human dopamine D2 receptor gene in alcoholism. Journal of American Medical Association, 263: 2055-2060.

Blum K, Sheridan PJ, Wood RC, Braverman ER, Chen TJ, Cull JG, Comings DE(1996) The D2 dopamine receptor gene as a determinant of reward deficiency syndrome. Journal Royal Society Medicine, 89:396-400.

Blum K, Trachtenberg MC, Elliott CE, Dingler ML, Sexton RL, Samuels AI, Cataldie L (1988) Enkephalinase inhibition and precursor amino acid loading improves inpatient treatment of alcohol and polydrug abusers: double-blind placebo-controlled study of the nutritional adjunct SAAVE. Alcohol, 5:):481-493.

Boundy VA, Pacheco MA, Guan W, Molinoff PB (1995) Agonists and antagonists differentially regulate the high affinity state of the D2L receptor in human embryonic kidney 293 cells. Molecular Pharmacology, 48(5): 956-964.

Brewer, C (1995) Second-line and “alternative” treatments for alcohol withdrawal; alpha-agonists, beta-blockers, anticonvulsants, acupuncture and neuro –electric therapy. Alcohol and Alcoholism 30 (6): 799-803.

Brown RJ, Blum K, Trachtenberg MC (1990) Neurodynamics of relapse prevention: a neuronutrient approach to outpatient DUI offenders. Journal Psychoactive Drugs 22: 173-187.

Bullock ML, Culliton P, Olander RT(1989) Controlled trial of acupuncture for severe recidivist alcoholism. Lancet, 1(8652): 1435.

Bullock ML, Kiresuk TJ, Pheley AM, Culliton PD, Lenz SK (1999) Auricular acupuncture in the treatment of cocaine abuse. A study of efficacy and dosing. Journal of Substance Abuse Treatment, 16(1): 31-38.

Cheng RS, Pomeranz B (1980) A combined treatment with D-amino acids and electroacupuncture produces a greater analgesia than either treatment alone; naloxone reverses these effects. Pain, 8(2): 231-236.

Chen TJ, Blum K, Wait RL, Meshkin B, Schoolfield J, Downs BW, Braverman ER, Arcuri V, Varshavskiy M, Blum SH, Mengucci. J, Reuben C, Palomo T (2007) Gene Narcotic Attenuation Program attenuates substance use disorder, a clinical subtype of reward deficiency syndrome. Advances in Therapy, 24(2):402-414.

Courbasson CM, de Sorkin AA, Dullerud B, Van Wyk L (2007) Acupuncture treatment for women with concurrent substance use and anxiety/depression: an effective alternative therapy? Family Community Health, 30(2): 112-120.

D'Alberto A (2004) Auricular acupuncture in the treatment of cocaine/crack abuse: a review of the efficacy, the use of the National Acupuncture Detoxification Association protocol, and the selection of sham points. Journal Alternative Complementary Medicine. 10(6): 985-1000.

Di Chiara G (1995) The role of dopamine in drug abuse viewed from the perspective of its role in motivation. Drug Alcohol and Dependence, 38(2): 95–137.

Durijan M, Ruben A (1980) An Introduction to the physiology of Auricular Reflex Therapy: International Meeting Of Acupuncture and Auriculomedicine, Madrid, Spain.

Gates S, Smith LA, Foxcroft DR (2006) Auricular acupuncture for cocaine dependence. Cochrane Database System Review, 25 (1): CD005192.

Gurevich MI, Duckworth D,., Imhof JE, Katz JL (1996) Is auricular acupuncture beneficial in the inpatient treatment of substance-abusing patients? A pilot study. Journal of Substance Abuse Treatment, 13 (2): 165-171.

Han J, Cui C, Wu L (2011) Acupuncture-related techniques for the treatment of opiate addiction: a case of translational medicine. Frontiers of Medicine, 5(2): 141-150.

Han JS, Shao LS(1990) Differential release of enkephalin and dynorphin by low and high frequency electro-acupuncture. Acupuncture, 1:1-9.

Handley A (2009) Straight to the point. Nursing Standards, 13-19; 23(36):22-24.

He D, Berg JE, Hostmark AT (1997) Effects of acupuncture on smoking cessation or reduction for motivated smokers. Preventive Medicine, 26 (2): 208-214.

Holder JM,Duncan RC,., Gissen M, Miller M, Blum K (2001) Increase in retention rates among the chemically dependent in residential treatment: auriculotherapy and subluxation- based chiropractic care. Molecular Psychiatry, 6 (suppl 1). S8.

Holder J, Smith M (1993) State of the Art treatment: Acupuncture, National Consortium of TASC Programs (NCPT), 3rd National Conference on Drugs and Crime Bulletin, Austin, Texas, 1993.

Kaliuzhnyĭ LV, Kozlov ALu (1991) Action of an enkephalinase blocker on the effect of acupuncture in acupuncture sensitive and resistant rabbits. Biulleten' eksperimental'noĭ biologii i meditsiny, 112(12): 571-3.

Kaptchuk T (1984) The Web That Has No Weaver. Congdon & Weed, New York, USA.

Maciocia G (1989) The Foundations of Chinese Medicine: A comprehensive Text for Acupunturists and Herbalists. Curchill-Livingstone, New York, USA.

Kitade T, Odahara Y, Shinohara S, Ikeuchi T, Sakai T, Morikawa K, Minamikawa M, Toyota S, Kawachi A, Hyodo M. et al. (1990) Studies on the enhanced effect of acupuncture analgesia and acupuncture anesthesia by D-phenylalanine (2nd report)--schedule of administration and clinical effects in low back pain and tooth extraction. Acupuncture Electrotherapy Results, 15(2): 121-35.

Kroenig RJ, Oleson TD (1985) Rapid narcotic detoxification on chronic pain patients treated with auricular electroacupuncture and Naloxone. International Journal of Addictions, 20 (9): 1347-60.

Lipton DS, Brewington V, Smith M (1994) Acupuncture for crack-cocaine detoxification: experimental evaluation of efficacy. Journal of Substance Abuse Treatment, 11(3): 205-15.

Man PL, Chaung MY (1980) Acupuncture in methadone withdrawal. International Journal of Addictions, 15 (6): 921-6.

Margolin A (2003) Acupuncture for substance abuse. Current Psychiatry Reports, 5: 333-9.

Martin GP, Waite PM (1981) The efficacy of acupuncture as an aid to stop smoking. New Zealand Medical Journal, 93 (686):421-3.

Micozzi M (1996) Chinese Medicine. In: Fundamentals of Complementary and Alternative Medicine. Churchill-Livingstone, New York, USA.

Mills EJ, Wu P, Gagnier J, Ebbert JO (2005) Efficacy of acupuncture for cocaine dependence: a systematic review & meta-analysis. Harm Reduction Journal. 17; 2(1):4.

Neiswanger K, Kaplan BB, Hill SY (1995) What can the DRD2/alcoholism story teach us about association studies in psychiatric genetics? American Journal of Medical Genetics, 60(4): 272-275.

Noble EP, Blum K, Khalsa ME, Ritchie T, Montgomery A, Wood RC, Fitch RJ, Ozkaragoz T (1993) Allelic association of the D2 dopamine receptor gene with cocaine dependence. Drug and Alcohol Dependence, 33(3): 271-285.

Nogier P (1972) Treatise of Auriculotherapy. Maisonneuve, Moulins- les Metz, France.

Oleson T (1998) The Auriculotherapy Manual, 2nd edition. UCLA, California, USA.

Otto KC (2003) Acupuncture and substance abuse: a synopsis, with indications for further research. American Journal on Addictions, 12(1):43-51.

Otto KC, Quinn C, Sung YF (1998) Auricular acupuncture as an adjunctive treatment for cocaine addiction. A pilot study. American Journal on Addictions, 7 (2): 164-70.

Peciña S, Smith KS, Berridge KC (2006) Hedonic hot spots in the brain. Neuroscientist, 12(12): 500–11.

Peng XQ, Xi ZX, Li X, Spiller K, Li J, Chun L, Wu KM, Froimowitz M, Gardner EL (2010) Is slow-onset long-acting monoamine transport blockade to cocaine as methadone is to heroin? Implication for anti-addiction medications. Neuropsychopharmacology, 35 (13): 2564-2578.

Pomeranz B, Cheng RS (1980) A combined treatment with D-Amino-acids and electroacupuncture produces a greater analgesia than either treatment alone: Naloxone reverses these effects. Pain, 8(2): 231-236.

Rothman RB, Glowa JR (1995) A review of the effects of dopaminergic agents on humans, animals, and drug-seeking behavior, and its implications for medication development. Molecular Neurobiology, 11(1-3): 1–19.

Russell LC, Sharp B, Gilbertson B, (2000) Acupuncture for addicted patients with chronic histories of arrest. A pilot study of the Consortium Treatment Center. Journal os Substance Abuse Treatment. 19(2):199-205.

Savants G, Margolin A, Holford T, Kosten T (2000) A randomized controlled trial of auricular acupuncture for cocaine dependence. Archives of Internal Medicine, 160: 2305-12.

Schuckit M (1993) Acupuncture and the treatment of drug withdrawal syndromes. Drug Abuse and Alcoholism Newsletter. October issue.

Smith MJ, Tong HC (2005) Manual acupuncture for analgesia during electromyography: a pilot study. Archives of physical medicine and rehabilitation, 86(9): 1741-4.

Ter Riet G, Kleijnen J, Knipschild P (1990) A meta-analysis of studies into the effect of acupuncture on addiction. The British journal of general practice, 40(338): 379-82.

Tindell AJ, Smith KS, Peciña S, Berridge KC, Aldridge JW (2006) Ventral pallidum firing codes hedonic reward: when a bad taste turns good. Journal of Neurophysiology, 96(5): 2399-2409.

United States Senate Subcommittee Minutes on Janet Reno/Jay Holder: Research on Ear Acupuncture and Auriculotherapy in Addiction Treatment, 103rd Congress, 1st session, Page 64, U.S. Government Printing Office, Washington, (1993).

Unschuld P (1985) Medicine In China. A History of Ideas. Berkeley University of California Press. Berkley USA.

Washburn AM, Fullilove RE, Fullilove MT, Keenan PA, McGee B, Morris KA, Sorensen JL, Clark WW (1993) Acupuncture heroin detoxification: a single – blind clinical trial. Journal of Substance Abuse Treatment, 10 (4): 345-51.

Whitehead PC (1978) Acupuncture in the treatment of addiction: a review and analysis. The International journal of the addictions, 13(1): 1-16.

Worner TM, Zeller B, Schwartz H, Zwas F, Lyon D (1992) Acupuncture fails to improve treatment outcome in alcoholics. Drug and Alcohol Dependence, 30(2): 169-73.

Wen HL (1977) Fast detoxification of heroin addicts by acupuncture and electrical stimulation (AES) in combination with naloxone. Comparative Medicine East and West. 5 (3-4): 257-63.

Zhu TM, Jin RJ, Zhong XM (2009) Clinical effect of electroacupuncture combined with psychologic interference on patient with Internet addiction disorder. Zhongguo Zhong Xi Yi Jie He Za Zhi, 29(3): 212-214.

Zhu TM, Jin RJ, Zhong XM, Chen J, Li H, (2008) Effects of electroacupuncture combined with psychologic interference on anxiety state and serum NE content in the patient of internet addiction disorder. Zhongguo Zhen Jiu, 28(8): 561-564.




DOI: https://doi.org/10.5195/iioablett.2011.9

Refbacks

  • There are currently no refbacks.




Copyright (c)